Check in: For all the isolation, you don't have to rough it here. In addition to boat-in and walk-in campgrounds, Two Harbors has the Banning House Lodge in the vacation home of Catalina's onetime owners. All 12 rooms have views of the harbor. From $128.
Explore: At Two Harbors, you can snorkel through swaying kelp beds and kayak to hidden coves. Steep trails lead into the Catalina backcountry. Or just stroll across the isthmus and look out over the Pacific: next stop, Hawaii, 2,500 miles away.